4-DHEA is a naturally occurring unmethylated (non-17aa) steroid.
4-DHEA, such as DHEA, requires a two-step conversion process involving 3b-HSD and 17b-HSD to convert it to androstenedione / maleenediol, followed by testosterone. DHEA is slightly different from the 4-DHEA is the fourth and not the fifth of the double key. This allows 4-DHEA to reduce estrogen by not directly acting on estrogen receptors (such as DHEA has been found).
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